Isotopically Labeled Compounds
Medchemexpress LLC Phenytoin-15N2,13C | 78213-26-0 | 99.8% | 120 UG
Phenytoin-15N2,13C is a 13C and 15N labeled derivative of Phenytoin (5,5-Diphenylhydantoin), known for its potent action as a Voltage-gated Na+ channels (VGSCs) blocker. It demonstrates antiepileptic activity and has been observed to reduce breast tumor growth and metastasis in mice. This compound incorporates stable heavy isotopes, making it suitable for use as a tracer in drug development for quantitative analysis.
- Can be utilized as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits antiepileptic activity
- Reduces breast tumor growth and metastasis
- Potential to influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC D-Glucose-13C-4 | 40762-22-9 | 98.0% | 50 MG
D-Glucose-13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology, a carbohydrate sweetener, and a critical component of general metabolism. It serves as a critical signaling molecule in relation to both cellular metabolic status and biotic and abiotic stress response. This product is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Venlafaxine-d10 hydrochloride | 1216539-56-8 | >98% | 2.5 MG
Venlafaxine-d10 hydrochloride is a deuterium labeled version of Venlafaxine hydrochloride, an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor, and an antidepressant. Intended for research use only, its deuteration may influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled Venlafaxine hydrochloride
- Potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits antidepressant properties
Medchemexpress LLC Pacritinib-d4 | 476.60 | 5 MG
Pacritinib-d4 (SB1518-d4) is the deuterium labeled Pacritinib. It is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). This compound also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Stable heavy isotopes have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Potent inhibitor of wild-type JAK2 and JAK2V617F mutant
- Inhibits FLT3 and its mutant FLT3D835Y
- Used as a tracer for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles
Medchemexpress LLC D-Sorbitol-d8 | 287962-59-8 | 98.9% | 1 MG
D-Sorbitol-d8 is a deuterium-labeled version of D-Sorbitol, a six-carbon sugar alcohol. D-Sorbitol can be used as a sugar substitute, stabilizing excipient, isotonicity agent, sweetener, humectant, thickener, and dietary supplement. This product is intended for research use only.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis
- Functions as a stabilizing excipient
- Acts as an isotonicity agent
- Serves as a sweetener
- Used as a humectant
- Functions as a thickener
- Can be used as a dietary supplement
Cambridge Isotope Laboratories L-TRYPTOPHAN (15N2, 98%), 0.25 G, 204634-20-8
L-TRYPTOPHAN (15N2, 98%), 0.25 G, 204634-20-8
Medchemexpress LLC Benzethonium-d7 chloride | 121-54-0 | 98.6% | 5 MG
Benzethonium-d7 chloride is a deuterium-labeled version of Benzethonium chloride. It is known to inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. This compound is valuable as a tracer and internal standard for quantitative analysis in drug development processes.
- Deuterium-labeled compound for tracer applications
- Inhibits human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Incorporates stable heavy isotopes for quantitation during drug development
Cambridge Isotope Laboratories 4-OXO-2,2,6,6-TETRAMETHYLPIPERIDINE (D17,97%;15N,97%+) TEMPONE PRECURSOR, 0.1 G
4-OXO-2,2,6,6-TETRAMETHYLPIPERIDINE (D17,97%;15N,97%+) TEMPONE PRECURSOR, 0.1 G
Medchemexpress LLC Citric acid-2,4-13C2 | 121633-50-9 | MFCD00143997 | 98.0% | 194.11 | C4(13C)2H8O7 | 10 MG
Citric acid-2,4-13C2 is a stable-isotope labeled form of citric acid with two 13C atoms incorporated at positions 2 and 4. It is provided as a small-quantity, research-grade material for analytical and biochemical applications, and is commonly used where isotopic tracing or internal standardization is required for quantitative methods.
- Stable 13C labeling at positions 2 and 4.
- Suitable as a tracer or internal standard for NMR, GC-MS, and LC-MS.
- High chemical purity for quantitative analysis.
- Supplied in laboratory-scale vial sizes for ease of use.
- Enables metabolic tracing and isotope-dilution experiments.
Cambridge Isotope Laboratories PROPIONIC ACID (2,2-D2, 98%), 5 G, 19136-91-5
PROPIONIC ACID (2,2-D2, 98%), 5 G, 19136-91-5
Medchemexpress LLC Sphingosine-1-phosphate | 26993-30-6 | 99.5% | 379.47 | 50 MG
Sphingosine-1-phosphate (S1P) acts as an agonist for S1P1-5 receptors and serves as a ligand for GPR3, GPR6, and GPR12. It functions as an intracellular second messenger and triggers Ca2+ mobilization as an extracellular ligand for G protein-coupled receptors. S1P is a crucial lipid mediator derived from Sphingomyelin or other membrane phospholipids.
- Promotes DNA synthesis.
- Promotes cell proliferation.
- Promotes migration.
- Acts as an intracellular second messenger.
- Triggers Ca2+ mobilization.
Medchemexpress LLC Alimemazine-d6 (Trimeprazine d6) | 1346603-88-0 | 99.6% | 10 MG
Alimemazine-d6 is a deuterium-labeled antihistamine intended for research use. It serves as a tracer and an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. This compound has a molecular weight of 304.48 and a formula of C18H16D6N2S, appearing as a white to off-white solid.
- Deuterium-labeled antihistamine
- Intended for research use
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, and LC-MS applications
- White to off-white solid appearance
Medchemexpress LLC 2-naphthol-d7 | 78832-54-9 | MFCD01074243 | 95.0% | 151.22 | C10HD7O | 25mg
2-Naphthol-d7 is the deuterium labeled 2-Naphthol[1] 2-Naphthol is a metabolite of naphthalene catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1 CYP 1A2 CYP 2A1 CYP 2E1 and CYP 2F2)[2]
Cambridge Isotope Laboratories WATER (18O, 10%), 10 G, 14314-42-2
WATER (18O, 10%), 10 G, 14314-42-2
Cambridge Isotope Laboratories 2 4 5-TriCB (PCB-31) (13C12 99%) 40 /-2 ug/mL in nonane 1 2 mL
2 4 5-TriCB (PCB-31) (13C12 99%) 40 /-2 ug/mL in nonane 1 2 mL